US 7,462,725 B2
Chloromethylation of thiophene
Mátyás Aradi, Budapest (Hungary); Ferenc Bakos, Budapest (Hungary); Zsolt Dombrády, Budapest (Hungary); Antal Gajáry, Budapest (Hungary); István Gyöngyösi, Budapest (Hungary); Ferenc Kovács, Budapest (Hungary); Andrea Major, Budapest (Hungary); Erika Máténé Török, Nagytarcsa (Hungary); Zsolt Párkányi, Budapest (Hungary); László Schultz, Budapest (Hungary); Attila Supic, Budapest (Hungary); Sándor Szabó, Budapest (Hungary); Erzsébet Szalay, Budapest (Hungary); József Ugrics, Budapest (Hungary); and József Zsiga, Dunakeszi (Hungary)
Assigned to Sanofi-Aventis, Paris (France)
Appl. No. 10/478,238
PCT Filed May 16, 2002, PCT No. PCT/HU02/00042
§ 371(c)(1), (2), (4) Date May 27, 2004,
PCT Pub. No. WO02/094806, PCT Pub. Date Nov. 28, 2002.
Claims priority of application No. 0102118 (HU), filed on May 22, 2001.
Prior Publication US 2006/0161008 A1, Jul. 20, 2006
Int. Cl. C07D 333/12 (2006.01)
U.S. Cl. 549—29 8 Claims
 
1. A process for the preparation of a compound of formula (I):

OG Complex Work Unit Drawing
by chloromethylation of thiophene, using aqueous concentrated hydrochloric acid, gaseous hydrogen chloride and paraformaldehyde, in the presence of one or more dialkyl-ketone type solvents.