US 7,462,645 B2
Bronchodilating beta-agonist compositions and methods
Imtiaz A. Chaudry, American Canyon, Calif. (US); Stephen Pham, Sacramento, Calif. (US); and Partha S. Banerjee, Wynnewood, Pa. (US)
Assigned to JPMorgan Chase Bank, N.A., Chicago, Ill. (US)
Filed on Mar. 20, 2007, as Appl. No. 11/688,429.
Application 11/688429 is a continuation of application No. 10/887785, filed on Jul. 09, 2004.
Claims priority of provisional application 60/486386, filed on Jul. 10, 2003.
Prior Publication US 2007/0160541 A1, Jul. 12, 2007
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/135 (2006.01)
U.S. Cl. 514—653 9 Claims
 
1. A method of treating undesired and/or uncontrolled bronchoconstriction comprising the steps of:
(a) adding to a nebulizer, from a propellant-free, sterile unit dose in pharmaceutical packaging material about 1 to about 3 mL of a pharmaceutical composition comprising formoterol or a salt thereof at a concentration of from about 0.08 μg/mL to about 43 μg/mL based on formoterol free base, in a pharmacologically suitable solution, wherein the composition further comprises water and a buffer selected from the group consisting of citric acid/phosphate buffer, acetate buffer, citrate buffer and phosphate buffer at a concentration of from about 1 mM to about 50 mM, said composition having a pH of between about 4.5 and about 5.5; and
(b) directly administering said composition to a subject in need thereof, without dilution or other modification of said prior to administration.