| US 7,579,485 B2 | ||
| Process for producing lactone | ||
| Makoto Kaneko, Yokohama (Japan); Yasuhiro Ninomiya, Yokohama (Japan); Tetsuji Nakamura, Yokohama (Japan); and Eiji Satou, Yokohama (Japan) | ||
| Assigned to Mitsubishi Rayon Co., Ltd., Tokyo (Japan) | ||
| Appl. No. 10/502,595 PCT Filed Feb. 03, 2003, PCT No. PCT/JP03/01060 § 371(c)(1), (2), (4) Date Jul. 27, 2004, PCT Pub. No. WO03/066617, PCT Pub. Date Aug. 14, 2003. |
||
| Claims priority of application No. 2002-032715 (JP), filed on Feb. 08, 2002. | ||
| Prior Publication US 2005/0080276 A1, Apr. 14, 2005 | ||
| Int. Cl. C07D 307/02 (2006.01) | ||
| U.S. Cl. 549—295 | 15 Claims |
| 1. A method for producing a γ-butyrolactone, which comprises:
reacting a 4-halo-butylamide of Formula (II):
 wherein X represents a halogen atom, and R1 to R6 each independently represents a hydrogen atom or any desired substituent,
with an aqueous medium at a pH of 2 to 4.5 to give a γ-butyrolactone of Formula (III):
 wherein R1 to R6 each independently represents a hydrogen atom or any desired substituent, and
wherein the 4-halo-butylamide of Formula (II) is a 4-halo-3-hydroxybutylamide; or wherein the 4-halo-butylamide of Formula
(II) is produced by nitrile hydratase treatment of a 4-halo-butyronitrile having Formula (IV):
 |