| US 7,550,752 B2 | ||
| Hadron treatment planning with adequate biological weighting | ||
| Cynthia E. Keppel, Norfolk, Va. (US); Richard A. Britten, Chesapeake, Va. (US); and Vahagn R. Nazaryan, Newport News, Va. (US) | ||
| Assigned to Hampton University, Hampton, Va. (US) | ||
| Filed on Mar. 27, 2007, as Appl. No. 11/727,584. | ||
| Claims priority of provisional application 60/786402, filed on Mar. 28, 2006. | ||
| Prior Publication US 2007/0228305 A1, Oct. 04, 2007 | ||
| Int. Cl. A61N 5/06 (2006.01) | ||
| U.S. Cl. 250—505.1 [250/494.1] | 25 Claims |
| 1. A method for delivering a biological dose at a treatment site of a patient, the method comprising the steps of:
determining a variability of relative biological effectiveness (RBE) along a line of each of a plurality of hadron beams;
calculating RBE values at a plurality of sections of a spread-out Bragg peak (SOBP) associated with the treatment site, wherein
the calculating takes into account the determined variability; and
adjusting an intensity and energy of each of the plurality of hadron beams at each of the plurality of sections of the spread-out
Bragg peak (SOBP) based on respective calculated RBE values for each of the plurality of sections to provide a calculated
dose distribution for each of the plurality of sections,
wherein the plurality of sections include a proximal part of SOBP area of the treatment site, a distal part of the SOBP, and
a declining distal edge part of the SOBP, and wherein the calculated dose distributions superimpose to provide a desired radiation
dose at the treatment site.
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