| US 7,550,560 B2 | ||
| Microwave-assisted peptide synthesis | ||
| Jonathan McKinnon Collins, Charlotte, N.C. (US); Joseph Joshua Lambert, Charlotte, N.C. (US); and Michael John Collins, Charlotte, N.C. (US) | ||
| Assigned to CEM Corporation, Matthews, N.C. (US) | ||
| Filed on Sep. 26, 2005, as Appl. No. 11/235,328. | ||
| Application 11/235328 is a division of application No. 10/604022, filed on Jun. 23, 2003. | ||
| Prior Publication US 2006/0025568 A1, Feb. 02, 2006 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. A61K 38/00 (2006.01); B01L 3/00 (2006.01) | ||
| U.S. Cl. 530—333 [422/99] | 29 Claims |
| 1. A vessel system for the microwave accelerated synthesis of peptides by the solid phase method, said vessel system comprising:
a reaction cell that is transparent to microwave radiation;
a first passageway in fluid communication with said cell for transferring solid phase resin between a resin source external
to said cell and said cell;
a second passageway in fluid communication between at least one amino acid source and said cell for adding amino acids to
said cell;
a third passageway in gaseous communication with an inert gas source and with a vent for applying gas pressure to and releasing
gas pressure from said cell so that the controlled flow of gases to and from said cell can be used to add and remove fluids
and flowing solids to and from said cell;
a fourth passageway in fluid communication between an external solvent source and said cell and terminating within said cell
with a spray head mechanism for flushing said cell with solvent
and a microwave source and a cavity for said vessel with said source being in wave communication with said cavity.
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