	US 7,550,450 B2
	Prostate cancer treatment
Henry A. Lardy, Madison, Wis. (US); Ashok Marwah, Middleton, Wis. (US); and Padma Marwah, Middleton, Wis. (US)
Assigned to Hollis-Eden Pharmaceuticals, Inc., San Diego, Calif. (US)
Filed on Sep. 26, 2007, as Appl. No. 11/862,153.
Application 11/862153 is a division of application No. 10/814503, filed on Mar. 30, 2004, abandoned.
Claims priority of provisional application 60/459450, filed on Apr. 01, 2003.
Prior Publication US 2008/0070881 A1, Mar. 20, 2008
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/58 (2006.01)

U.S. Cl. 514—173

4 Claims

1. A method to treat prostate cancer in a subject in need thereof, comprising administering an effective amount of a compound having the structure

wherein

E is —C(O)— or —CR⁵R⁶—;

G is —CR³R⁴—;

K is —CR¹R²—;

R¹is —OR¹¹

R²is —H, lower alkyl or substituted lower alkyl;

R³and R⁵independently are —H, —OH or lower alkyl;

R⁴and R⁶independently are —H or lower alkyl;

R¹¹is —H, alkyl or substituted alkyl, —C(O)—R¹², —S(O)_0-2—R¹²or —C(O)—OR¹²;

R¹²is —H, alkyl or substituted alkyl;

R is —OH or unsubstituted lower alkoxy;

R′ is —F or unsubstituted lower alkyl;

n is 0 or 1; and

n′ is 0 or 1.