| US 7,550,441 B2 | ||
| Controlled release polymer nanoparticle containing bound nucleic acid ligand for targeting | ||
| Omid C. Farokhzad, Boston, Mass. (US); Sangyong Jon, Gwangju (Korea, Republic of); and Robert S. Langer, Newton, Mass. (US) | ||
| Assigned to Massachusetts Institute of Technology, Boston, Mass. (US) | ||
| Filed on Jun. 04, 2004, as Appl. No. 10/860,918. | ||
| Application 10/860918 is a continuation in part of application No. 10/456978, filed on Jun. 06, 2003. | ||
| Prior Publication US 2005/0037075 A1, Feb. 17, 2005 | ||
| Int. Cl. A61K 31/7088 (2006.01); A61K 31/713 (2006.01); A61K 9/14 (2006.01); C12Q 1/00 (2006.01); C12N 11/00 (2006.01) | ||
| U.S. Cl. 514—44 [514/2; 424/489; 435/4; 435/174] | 37 Claims |
| 1. A controlled release polymer nanoparticle, comprising;
a therapeutic or diagnostic agent incorporated in the controlled release polymer nanoparticle; and
a nucleic acid ligand comprising an oligonucleotide bound to the surface of the controlled release polymer nanoparticle that
selectively binds to a target cell or tissue, and thereby delivers the controlled release polymer nanoparticle to the target
cell or tissue;
wherein the controlled release polymer nanoparticle carries a neutral to negative charge on its surface; and
wherein the bound oligonucleotide has a folded three-dimensional conformation resulting from intramolecular interactions.
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