| US 7,550,428 B2 | ||
| Echinocandin/carbohydrate complexes | ||
| Larry A. Larew, Zionsville, Ind. (US); Nathaniel Milton, Indianapolis, Ind. (US); James Lawrence Sabatowski, Holland, Mich. (US); and Kenneth Philip Moder, West Lafayette, Ind. (US) | ||
| Assigned to Eli Lilly and Company, Indianapolis, Ind. (US) | ||
| Filed on Aug. 30, 2005, as Appl. No. 11/216,773. | ||
| Application 11/216773 is a division of application No. 09/942458, filed on Aug. 29, 2001, granted, now 7,041,637. | ||
| Application 09/942458 is a continuation of application No. PCT/US00/05508, filed on Mar. 02, 2000. | ||
| Claims priority of provisional application 60/122692, filed on Mar. 03, 1999. | ||
| Prior Publication US 2006/0111277 A1, May 25, 2006 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. A61K 38/00 (2006.01) | ||
| U.S. Cl. 514—7 [514/8; 530/317] | 10 Claims |
1. A method for treating a fungal infection in a mammal in need thereof, which comprises administering to said mammal the
echinocandin/carbohydrate complex comprising a carbohydrate and an echinocandin compound represented by the following structure:
 R is an alkyl group, an alkenyl group, an alkynyl group, an aryl group, heteroaryl group, or combinations thereof;
R1, R2, R3, R6, R7, and R10 are independently hydroxy or hydrogen;
R4 is hydrogen, methyl or —CH2C(O)NH2;
R5 and R11 are independently methyl or hydrogen;
R8 is —OH, —OSO3H, —OPO3H2, —OPO3HRa, or —OPO2HRa, where Ra is hydroxy, C1-C6 alkyl, C1-C6alkoxy, phenyl, phenoxy, p-halophenyl, p-halophenoxy, p-nitrophenyl, p-nitrophenoxy, benzyl, benzyloxy, p-halobenzyl, p-halobenzyloxy,
p-nitrobenzyl, or p-nitrobenzyloxy;
R9 is —H, —OH, or —OSO3H; and
pharmaceutically acceptable salts or hydrates thereof;
wherein the carbohydrate is released upon dispersion of the echinocandin/carbohydrate complex in water.
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