| US 7,550,427 B2 | ||
| Poly-pegylated protease inhibitors | ||
| Arthur C. Ley, Newton, Mass. (US); Aaron K Sato, Somerville, Mass. (US); Robert C. Ladner, Ijamsville, Md. (US); and Mark Stochl, North Attleboro, Mass. (US) | ||
| Assigned to Dyax Corp., Cambridge, Mass. (US) | ||
| Filed on Jul. 20, 2006, as Appl. No. 11/458,773. | ||
| Application 11/458773 is a continuation of application No. 10/931153, filed on Aug. 30, 2004, abandoned. | ||
| Claims priority of provisional application 60/498845, filed on Aug. 29, 2003. | ||
| Claims priority of provisional application 60/598967, filed on Aug. 04, 2004. | ||
| Prior Publication US 2007/0041959 A1, Feb. 22, 2007 | ||
| Int. Cl. A61K 38/55 (2006.01); C07K 14/81 (2006.01) | ||
| U.S. Cl. 514—2 [530/324] | 48 Claims |
| 1. A compound comprising:
(i) a Kunitz domain peptide that comprises the DX-890 amino acid sequence set forth in SEQ ID NO:23 or an amino acid sequence
that differs by at least one, but no more than five, amino acid alterations from the DX-890 amino acid sequence set forth
in SEQ ID NO:23 and that binds to and inhibits a protease; and
(ii) a plurality of polyethylene glycol moieties covalently attached to at least each of four primary amines of the Kunitz
domain peptide, wherein the average molecular weight of each of the moieties is between 3 kDa and 12 kDa.
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