| US 7,550,133 B2 | ||
| Respiratory drug condensation aerosols and methods of making and using them | ||
| Ron L. Hale, Woodside, Calif. (US); Peter M. Lloyd, Walnut Creek, Calif. (US); Amy T. Lu, Los Altos, Calif. (US); Joshua D. Rabinowitz, Mountain View, Calif. (US); and Martin J. Wensley, San Francisco, Calif. (US) | ||
| Assigned to Alexza Pharmaceuticals, Inc., Mountain View, Calif. (US) | ||
| Filed on Nov. 20, 2003, as Appl. No. 10/719,899. | ||
| Claims priority of provisional application 60/429364, filed on Nov. 26, 2002. | ||
| Prior Publication US 2004/0105819 A1, Jun. 03, 2004 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. A61K 9/12 (2006.01); A61K 9/14 (2006.01); A61M 15/00 (2006.01) | ||
| U.S. Cl. 424—45 [424/46; 424/489; 424/434; 424/499; 514/958; 128/200.14; 128/200.24; 128/203.15] | 46 Claims |
| 1. A composition for delivery of a drug, the compostion comprising a condensation aerosol
a) wherein the condensation aerosol is formed by heating a thin film of a drug composition to produce a vapor, and condensing
the vapor to form a condensation aerosol comprising the drug,
b) wherein the condensation aerosol comprises particles that are characterized by less than 10% drug degradation products
by weight,
c) wherein the condensation aerosol has an MMAD of less than 5 microns, and
d) wherein the drug is selected from the group consisting of albuterol, epinephrine, metaproterenol, terbutaline, pseudoephedrine
hydrochloride, bambuterol, bitolterol, carbuterol, clenbuterol, clorprenalin, dioxethedrine, eprozinol, etefedrine, ethylnorepinephrine,
fenoterol, fenspiride, hexoprenaline, isoetharine, isoproterenol, mabuterol, methoxyphenamine, pirbuterol, procaterol, protokylol,
rimiterol, salmeterol, soterenol, tretoquinol, tulobuterol, theophylline, aminophylline, acefylline, bamifylline, doxofylline,
dyphylline, etamiphyllin, etofylline, proxyphylline, reproterol, theobromine-1-acetic acid, atropine, ipratropium bromide,
flutropium bromide, oxitropium bromide, tiotropium bromide, budesonide, beclomethasone, ciclesonide, dexamethasone, flunisolide,
fluticasone propionate, triamcinolone acetonide, prednisolone, methylprednisolone, hydrocortisone, cromolyn sodium, nedocromil
sodium, montelukast, zafirlukast, pirfenidone, CPX, IBMX, cilomilast, roflumilast, pumafentrine, domitroban, israpafant, ramatroban,
seratrodast, tiaramide, zileuton, ambrisentan, bosentan, enrasentan, sitaxsentan, tezosentan, iloprost, and treprostinil.
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