US 7,476,735 B2
	Compounds and methods for labeling oligonucleotides
Andrei Laikhter, Iowa City, Iowa (US); Joseph A. Walder, Chicago, Ill. (US); Mark Behlke, Coralville, Iowa (US); Mikhail Podyminogin, Coralville, Iowa (US); and Yawful Yong, Coralville, Iowa (US)
Assigned to Integrated DNA Technologies, Inc., Skokie, Ill. (US)
Filed on May 22, 2006, as Appl. No. 11/438,606.
Claims priority of provisional application 60/683278, filed on May 20, 2005.
Prior Publication US 2006/0263816 A1, Nov. 23, 2006
Int. Cl. C07H 19/04 (2006.01); C07H 21/00 (2006.01); C12Q 1/68 (2006.01); C07C 245/00 (2006.01); C07K 16/00 (2006.01)

U.S. Cl. 536—26.6  [536/25.32; 435/6; 534/558; 530/391.3]

8 Claims

1. A method for linking a reporter moiety to an oligonucleotide comprising reacting a reporter moiety having an oxime forming nucleophile substituent with an oxo substituted reactant coupled to a solid support to form an oxime bond between the reporter moiety and the reactant.