US 7,476,651 B2
Tryptophanyl-tRNA synthetase-derived polypeptides useful for the regulation of angiogenesis
Paul Schimmel, La Jolla, Calif. (US); Keisuke Wakasugi, Shizuok (Japan); and Martin Friedlander, Del Mar, Calif. (US)
Assigned to The Scripps Research Institute, La Jolla, Calif. (US)
Filed on Sep. 20, 2007, as Appl. No. 11/903,030.
Application 11/903030 is a division of application No. 10/982014, filed on Nov. 04, 2004, granted, now 7,273,844.
Application 10/982014 is a continuation in part of application No. 10/240527, granted, now 7,144,984, previously published as PCT/US01/08966, filed on Mar. 21, 2001.
Application 10/240527 is a continuation in part of application No. 10/240532, granted, now 7,067,126, previously published as PCT/US01/08975, filed on Mar. 21, 2001.
Application 10/240532 is a continuation in part of application No. 10/080839, filed on Feb. 22, 2002, abandoned.
Claims priority of provisional application 60/270951, filed on Feb. 23, 2001.
Claims priority of provisional application 60/193471, filed on Mar. 31, 2000.
Prior Publication US 2008/0064639 A1, Mar. 13, 2008
Int. Cl. A61K 38/00 (2006.01); C12N 9/10 (2006.01)
U.S. Cl. 514—2  [530/300; 530/350; 435/193] 17 Claims
 
1. A method for inhibiting ocular neovascularization in a patient, the method comprising administering to a patient an ocular neovascularization inhibiting amount of a water-soluble polypeptide selected from the group consisting of SEQ ID NO: 12, SEQ ID NO: 7, and an ocular neovascularization inhibiting fragment thereof, the fragment including at least one of amino acid residue signature sequences HVGH (SEQ ID NO:10) and KMSAS (SEQ ID NO:11).